SCGB2A1

Across TCGA pan-cancer cohorts, SCGB2A1 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated SCGB2A1 data layer compared with 19 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SCGB2A1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SCGB2A1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC and UCEC are the cancer types where SCGB2A1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.534	0.914	.043	4	view →
UCEC	OS	Tertile	All	1.000	0.859	.011	2	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

SCGB2A1–HNSC (OS)

Open the HNSC breakdown →