Across TCGA pan-cancer cohorts, SCGB1C1 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of SCGB1C1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SCGB1C1 RNA is repressed in tumor relative to normal tissue. In most cancer types SCGB1C1 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and KIRP are the cancer types where SCGB1C1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SCGB1C1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	−0.132	<.001	11	view →
KICH	Male	All	−0.529	<.001	9	view →
KIRP	All	All	−0.158	<.001	6	view →
LUAD	Female	II,III,IV	−0.074	.018	2	view →
COAD	All	II,III,IV	−0.032	.011	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: SCGB1C1 RNA expression & survival · all SCGB1C1 data types