SCFD2

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, SCFD2 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCFD2-associated genes across cancer lineages are p62 Lck ligand, PCNA, and Shc_pY317. Each is linked with SCFD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SCFD2-to-partner and partner-to-SCFD2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCFD2→partner) and Y-score (partner→SCFD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECp62 Lck ligand →+0.515+2.392<.001<.00132
UCECPCNA →+0.230+2.906.002.00132
UCECShc_pY317 →-0.163-2.000.002.00332
UCECTFRC →+0.530+3.700.004.00132
UCECBcl-2 →-0.261-1.335.033.03732
UCECCaspase-7-cleavedD198 →+0.582+1.604.005.02132
Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Exploration