Across TCGA cell cohorts, SCFD2 mutation is significantly associated with the RNA expression of many other genes, with 92 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SCFD2-associated genes across cancer lineages are FXYD4, MCAT, and HAND1. Each is linked with SCFD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SCFD2-to-partner and partner-to-SCFD2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCFD2→partner) and Y-score (partner→SCFD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	FXYD4 →	+0.161	+4.977	<.001	.007	3	1
LARGE_INTESTINE	MCAT →	+0.568	+3.364	.007	.002	3	1
LARGE_INTESTINE	HAND1 →	+0.860	+2.736	.003	.004	3	1
LARGE_INTESTINE	MRPL37 →	+0.447	+3.451	.008	.002	3	1
LARGE_INTESTINE	TSFM →	+0.581	+3.364	<.001	.002	3	1
LARGE_INTESTINE	MRPL39 →	+0.580	+3.082	.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 92 associations by consensus.

Exploration

SCFD2 survival (RNA) · tumor vs normal (RNA) · all SCFD2 data types