SCFD1

Across TCGA pan-cancer cohorts, SCFD1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SCFD1 data layer compared with 27 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SCFD1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SCFD1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

HNSC, LUAD, and PDAC are the cancer types where SCFD1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	1.000	0.291	.001	35	view →
LUAD	OS	Tertile	All	0.724	0.941	.011	10	view →
PDAC	DFS	Median	IV	0.214	0.785	.006	9	view →
LSCC	DFS	Median	All	0.907	0.464	.009	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SCFD1–HNSC (DFS)

Open the HNSC breakdown →