SCEL

Across TCGA pan-cancer cohorts, SCEL Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated SCEL data layer compared with 21 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher SCEL Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SCEL expression acts as an unfavorable survival marker, although some lineages such as SKCM and SCLC show a favorable association.

COAD, SKCM, and SCLC are the cancer types where SCEL Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	III,IV	0.208	0.791	.008	9	view →
SKCM	OS	Median	All	1.000	0.762	.026	8	view →
SCLC	DFS	Median	II,III,IV	1.000	0.551	.022	7	view →
ACC	DFS	Median	All	0.089	0.666	.017	6	view →
PRAD	OS	Median	All	0.369	0.887	<.001	6	view →
SARC	DFS	Median	All	0.179	0.612	.024	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

SCEL–COAD (OS)

Open the COAD breakdown →