SCEL

Across TCGA patient cohorts, SCEL mutation is significantly associated with the RNA expression of many other genes, with 4,720 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCEL-associated genes across cancer lineages are OR6B1, RPL22P14, and DNAJC9. Each is linked with SCEL in more than 2 cancer types. Because this analysis shows association rather than direction, both SCEL-to-partner and partner-to-SCEL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6B1 grouped by SCEL-low versus SCEL-high in SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCEL→partner) and Y-score (partner→SCEL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	OR6B1 →	+0.118	+5.228	<.001	.002	3	3
LIHC	RPL22P14 →	+0.114	+4.544	<.001	.009	3	3
UCEC	DNAJC9 →	+0.540	+2.329	.001	<.001	3	3
UCEC	POLR3K →	+0.452	+2.126	<.001	<.001	3	3
UCEC	PGAM1 →	+0.714	+2.606	<.001	<.001	3	3
UCEC	NDUFAB1 →	+0.510	+3.326	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,720 associations by consensus.

OR6B1 by SCEL expression — SCLC

Explore this box plot interactively →