SCEL

Across TCGA patient cohorts, SCEL mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCEL-associated genes across cancer lineages are Shc_pY317, ASNS, and MEK1. Each is linked with SCEL in more than 2 cancer types. Because this analysis shows association rather than direction, both SCEL-to-partner and partner-to-SCEL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by SCEL-low versus SCEL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCEL→partner) and Y-score (partner→SCEL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Shc_pY317 →	-0.150	-1.584	.003	.009	3	3
UCEC	ASNS →	+0.379	+2.000	.001	.009	3	3
UCEC	MEK1 →	+0.456	+2.201	<.001	<.001	3	2
LUSC	PCNA →	+0.221	+3.009	.046	.019	3	2
UCEC	eIF4E →	+0.204	+3.713	.003	<.001	3	2
SKCM	ER-alpha →	-0.150	-1.966	.022	.027	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

Shc_pY317 by SCEL expression — UCEC

Explore this box plot interactively →