SCEL

Across TCGA cell cohorts, SCEL RNA expression is significantly associated with the go_rna of many other GO terms, with 3,357 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible SCEL-associated GO terms across cancer lineages are Epithelial cell-cell adhesion, Regulation of ruffle assembly, and Small GTPase-mediated signal transduction. Each is linked with SCEL in more than 10 cancer types. Because this analysis shows association rather than direction, both SCEL-to-partner and partner-to-SCEL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Epithelial cell-cell adhesion grouped by SCEL-low versus SCEL-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SCEL→partner) and Y-score (partner→SCEL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Epithelial cell-cell adhesion →	+0.207	+2.344	.001	.008	3	11
LARGE_INTESTINE	Regulation of ruffle assembly →	+0.149	+2.198	<.001	<.001	3	11
OESOPHAGUS	Small GTPase-mediated signal transduction →	+0.083	+4.201	.001	<.001	3	11
URINARY_TRACT	Response to indole-3-methanol →	+0.222	+3.216	<.001	<.001	3	11
PANCREAS	Cellular response to indole-3-methanol →	+0.213	+3.897	<.001	<.001	3	11
PANCREAS	Cell-substrate junction assembly →	+0.190	+3.455	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,357 associations by consensus.

Epithelial cell-cell adhesion by SCEL expression — URINARY_TRACT

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