SCD

Across TCGA pan-cancer cohorts, SCD mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of SCD’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where SCD mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types SCD is over-expressed in tumor.

CCRCC, LSCC, and COAD are the cancer types where SCD tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SCD mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	IV	+2.237	<.001	11	view →
LSCC	Male	II,III,IV	+0.809	<.001	8	view →
COAD	All	II,III,IV	+0.670	<.001	6	view →
LUAD	All	III,IV	+0.448	.002	3	view →
HNSC	All	III,IV	+0.332	.034	3	view →
PDAC	Female	All	+0.650	.006	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

SCD–CCRCC

Open the CCRCC breakdown →