SCD

Across TCGA patient cohorts, SCD protein abundance is significantly associated with the RNA expression of many other genes, with 12,450 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SCD-associated genes across cancer lineages are SCDP1, HMGCS1, and GYPC. Each is linked with SCD in more than 6 cancer types. Because this analysis shows association rather than direction, both SCD-to-partner and partner-to-SCD results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SCD versus SCDP1 in UCEC, with a Pearson correlation of 0.39.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCD→partner) and Y-score (partner→SCD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SCDP1 →	+1.211	+0.830	.001	<.001	3	7
HNSC	HMGCS1 →	+0.905	+0.983	<.001	<.001	3	5
UCEC	GYPC →	-0.759	-0.855	.001	<.001	3	5
LSCC	TNXB →	-1.015	-0.840	<.001	<.001	3	5
LSCC	ADH1B →	-1.482	-0.658	<.001	<.001	3	5
BRCA	IDI1 →	+0.792	+0.897	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,450 associations by consensus.

SCD vs SCDP1 — UCEC

Explore this scatter interactively →