SCD

Across TCGA patient cohorts, SCD mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCD-associated genes across cancer lineages are eEF2, EGFR_pY1068, and eIF4G. Each is linked with SCD in more than 1 cancer types. Because this analysis shows association rather than direction, both SCD-to-partner and partner-to-SCD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by SCD-low versus SCD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCD→partner) and Y-score (partner→SCD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.317	+1.662	.012	.011	3	1
UCEC	EGFR_pY1068 →	-0.303	-3.087	<.001	<.001	3	1
UCEC	eIF4G →	+0.339	+2.700	.001	.005	3	1
UCEC	A-Raf_pS299 →	-0.103	-2.115	.014	.017	3	1
UCEC	ERK2 →	+0.215	+2.700	.001	.005	3	1
UCEC	Gab2 →	+0.368	+2.000	.003	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

eEF2 by SCD expression — UCEC

Explore this box plot interactively →