SCCPDH

Across TCGA pan-cancer cohorts, SCCPDH mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SCCPDH data layer compared with 25 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SCCPDH mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SCCPDH expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

HNSC, GBM, and LSCC are the cancer types where SCCPDH mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	II,III,IV	0.870	0.979	.015	23	view →
GBM	DFS	Tertile	All	0.874	0.628	.004	14	view →
LSCC	DFS	Median	II,III,IV	0.485	1.000	.006	11	view →
PDAC	DFS	Median	IV	0.214	0.785	.006	9	view →
LUAD	OS	Tertile	III,IV	0.757	1.000	.022	4	view →
UCEC	DFS	Median	All	0.845	0.961	.022	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SCCPDH–HNSC (DFS)

Open the HNSC breakdown →