SCCPDH

Across TCGA patient cohorts, SCCPDH mutation is significantly associated with the RNA expression of many other genes, with 2,412 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCCPDH-associated genes across cancer lineages are RNA5SP423, ELAVL4-AS1, and OR11G1P. Each is linked with SCCPDH in more than 2 cancer types. Because this analysis shows association rather than direction, both SCCPDH-to-partner and partner-to-SCCPDH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP423 grouped by SCCPDH-low versus SCCPDH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCCPDH→partner) and Y-score (partner→SCCPDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP423 →	+0.842	+2.717	<.001	<.001	3	3
CESC	ELAVL4-AS1 →	+0.165	+5.103	<.001	.008	3	2
CESC	OR11G1P →	+0.037	+5.969	<.001	.002	3	2
CESC	RNU6-737P →	+0.297	+5.969	.001	.002	3	2
CESC	RAET1M →	+0.061	+5.418	.002	.005	3	2
CESC	RNU6-1133P →	+0.299	+5.669	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,412 associations by consensus.

RNA5SP423 by SCCPDH expression — UCEC

Explore this box plot interactively →