SCCPDH

Across TCGA patient cohorts, SCCPDH mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCCPDH-associated genes across cancer lineages are Caspase-8, FoxM1, and JNK2. Each is linked with SCCPDH in more than 1 cancer types. Because this analysis shows association rather than direction, both SCCPDH-to-partner and partner-to-SCCPDH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-8 grouped by SCCPDH-low versus SCCPDH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCCPDH→partner) and Y-score (partner→SCCPDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-8 →	-0.264	-2.780	.011	.003	3	2
UCEC	FoxM1 →	+0.213	+3.331	.046	.005	3	1
UCEC	JNK2 →	+0.194	+2.196	.018	.032	3	1
UCEC	p27_pT198 →	+0.096	+2.321	.030	.006	3	1
UCEC	p62 Lck ligand →	+0.430	+3.594	.001	.001	3	1
UCEC	Rab25 →	-0.370	-2.999	.006	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Caspase-8 by SCCPDH expression — UCEC

Explore this box plot interactively →