SCAT8

Across TCGA pan-cancer cohorts, SCAT8 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated SCAT8 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SCAT8 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SCAT8 expression acts as an unfavorable survival marker, although some lineages such as SKCM and LUSC show a favorable association.

HNSC, KIRC, and BLCA are the cancer types where SCAT8 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.518	0.688	<.001	146	view →
KIRC	OS	Median	All	0.544	0.722	<.001	108	view →
BLCA	OS	Median	All	0.647	0.764	<.001	103	view →
ACC	DFS	Quartile	All	0.404	0.847	<.001	83	view →
STAD	DFS	Median	All	0.324	0.477	<.001	79	view →
KIRP	DFS	Quartile	II,III,IV	0.359	0.813	<.001	62	view →
SKCM	OS	Median	II,III,IV	0.424	0.242	.005	24	view →
LAML	DFS	Tertile	All	0.433	0.721	.009	24	view →
LUSC	OS	Tertile	All	0.841	0.755	.008	15	view →
UVM	DFS	Tertile	All	0.546	0.774	.041	15	view →
CESC	DFS	Tertile	All	0.509	0.694	.013	14	view →
READ	OS	Tertile	II,III,IV	0.820	1.000	.011	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

SCAT8–HNSC (DFS)

Open the HNSC breakdown →