Across TCGA pan-cancer cohorts, SCART1 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of SCART1’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SCART1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SCART1 is over-expressed in tumor, although a few such as HNSC show the opposite, repressed pattern.
KIRC, COAD, and CHOL are the cancer types where SCART1 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SCART1 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.