Across TCGA pan-cancer cohorts, SCARNA23 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of SCARNA23’s most consistent transcriptional readouts.
The strongest signal is observed in stomach adenocarcinoma (STAD), where SCARNA23 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SCARNA23 is over-expressed in tumor.
STAD, LUSC, and HNSC are the cancer types where SCARNA23 tumor–normal differential expression is most reproducible.