Across TCGA pan-cancer cohorts, SCARNA1 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of SCARNA1’s most consistent transcriptional readouts.
The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where SCARNA1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SCARNA1 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.
UCEC, CHOL, and THCA are the cancer types where SCARNA1 tumor–normal differential expression is most reproducible.