SCARF2

Across TCGA cell cohorts, SCARF2 mutation is significantly associated with the mutation status of many other genes, with 5,428 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SCARF2-associated genes across cancer lineages are MYO7A, HUWE1, and BSN. Each is linked with SCARF2 in more than 4 cancer types. Because this analysis shows association rather than direction, both SCARF2-to-partner and partner-to-SCARF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYO7A grouped by SCARF2-low versus SCARF2-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCARF2→partner) and Y-score (partner→SCARF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	MYO7A →	+4.392	+4.954	.008	.008	1	5
BLOOD_Lymphoma	HUWE1 →	+2.847	+4.327	.006	.006	1	5
LARGE_INTESTINE	BSN →	+1.734	+3.282	<.001	<.001	1	5
UPPER_AERODIGESTIVE_TRACT	LAMA4 →	+4.392	+4.954	.008	.008	1	4
BLOOD_Lymphoma	ABCA6 →	+4.584	+4.584	.007	.007	1	4
UPPER_AERODIGESTIVE_TRACT	ADGRB1 →	+5.392	+5.392	.004	.004	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,428 associations by consensus.

MYO7A by SCARF2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →