SCARF1

Across TCGA pan-cancer cohorts, SCARF1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SCARF1 data layer compared with 28 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher SCARF1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SCARF1 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

PDAC, UCEC, and HNSC are the cancer types where SCARF1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	All	0.622	0.860	.004	24	view →
UCEC	DFS	Median	All	0.769	0.947	.005	8	view →
HNSC	DFS	Quartile	III,IV	0.696	0.415	.004	8	view →
CCRCC	DFS	Tertile	All	0.521	1.000	.012	5	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SCARF1–PDAC (DFS)

Open the PDAC breakdown →