SCARF1

Across TCGA patient cohorts, SCARF1 mutation is significantly associated with the immune_cell of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCARF1-associated genes across cancer lineages are Melanocytes, Astrocytes, and Th2 cells. Each is linked with SCARF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SCARF1-to-partner and partner-to-SCARF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Melanocytes grouped by SCARF1-low versus SCARF1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCARF1→partner) and Y-score (partner→SCARF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Melanocytes →	+0.014	+2.901	.010	.031	3	2
SKCM	Astrocytes →	+0.058	+1.932	<.001	.006	3	2
LUSC	Th2 cells →	-0.255	-3.000	.019	.037	3	1
UCEC	lymphatic Endothelial cells →	-0.021	-1.959	.041	.031	3	1
UCEC	Mesangial cells →	-0.044	-2.936	.009	.036	3	1
COAD	Myocytes →	+0.046	+3.183	.010	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Melanocytes by SCARF1 expression — COAD

Explore this box plot interactively →