SCARB2

Across TCGA pan-cancer cohorts, SCARB2 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of SCARB2’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where SCARB2 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types SCARB2 is over-expressed in tumor, although a few such as LSCC and PDAC show the opposite, repressed pattern.

LSCC, CCRCC, and LUAD are the cancer types where SCARB2 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SCARB2 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	II,III,IV	−0.436	<.001	8	view →
CCRCC	Male	II,III,IV	+0.244	<.001	6	view →
LUAD	All	All	+0.141	.003	4	view →
HNSC	Male	IV	+0.234	.017	2	view →
PDAC	All	All	−0.219	.021	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

SCARB2–LSCC

Open the LSCC breakdown →