SCARB2

Across TCGA patient cohorts, SCARB2 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCARB2-associated genes across cancer lineages are ATM, Bcl-2, and Caspase-7-cleavedD198. Each is linked with SCARB2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SCARB2-to-partner and partner-to-SCARB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by SCARB2-low versus SCARB2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCARB2→partner) and Y-score (partner→SCARB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.564	-2.446	.001	.018	3	2
COAD	Bcl-2 →	+0.334	+2.815	.027	.036	3	1
COAD	Caspase-7-cleavedD198 →	+1.376	+2.815	.001	.036	1	3
COAD	CD20 →	+0.190	+2.832	.007	.035	3	1
COAD	Cyclin-D1 →	+0.146	+2.815	.042	.036	3	1
UCEC	eIF4E →	+0.211	+3.700	.010	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

ATM by SCARB2 expression — UCEC

Explore this box plot interactively →