SCARB2

Across TCGA cell cohorts, SCARB2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,096 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SCARB2-associated GO terms across cancer lineages are Regulation of endosome organization, ER-nucleus signaling pathway, and Protein deglycosylation. Each is linked with SCARB2 in more than 19 cancer types. Because this analysis shows association rather than direction, both SCARB2-to-partner and partner-to-SCARB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of endosome organization grouped by SCARB2-low versus SCARB2-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SCARB2→partner) and Y-score (partner→SCARB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of endosome organization →	+0.220	+0.910	<.001	<.001	3	20
BONE	ER-nucleus signaling pathway →	+0.121	+1.593	.001	<.001	3	15
BONE	Protein deglycosylation →	+0.118	+1.188	<.001	<.001	3	14
OESOPHAGUS	Positive regulation of ER to Golgi vesicle-mediated transport →	+0.133	+1.029	<.001	<.001	3	14
BONE	Protein demannosylation →	+0.112	+1.244	<.001	<.001	3	14
BONE	Protein alpha-1,2-demannosylation →	+0.112	+1.244	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,096 associations by consensus.

Regulation of endosome organization by SCARB2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →