SCARB2

Across TCGA cell cohorts, SCARB2 mutation is significantly associated with the mutation status of many other genes, with 651 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SCARB2-associated genes across cancer lineages are ZNF112, CUL3, and REM1. Each is linked with SCARB2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SCARB2-to-partner and partner-to-SCARB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF112 grouped by SCARB2-low versus SCARB2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCARB2→partner) and Y-score (partner→SCARB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ZNF112 →	+4.736	+5.560	.003	.003	1	3
BLOOD_Leukemia	CUL3 →	+4.736	+5.560	.003	.003	1	2
LARGE_INTESTINE	REM1 →	+4.523	+5.087	.006	.006	1	2
LARGE_INTESTINE	TGFB2 →	+4.523	+5.087	.006	.006	1	2
BLOOD_Leukemia	ZMYND15 →	+5.321	+5.894	.002	.002	1	2
BLOOD_Leukemia	THRB →	+4.000	+5.050	.008	.008	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 651 associations by consensus.

ZNF112 by SCARB2 expression — BLOOD_Leukemia

Explore this box plot interactively →