SCARA5

Across TCGA patient cohorts, SCARA5 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCARA5-associated genes across cancer lineages are FoxM1, eIF4E, and JNK_pT183_Y185. Each is linked with SCARA5 in more than 2 cancer types. Because this analysis shows association rather than direction, both SCARA5-to-partner and partner-to-SCARA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by SCARA5-low versus SCARA5-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCARA5→partner) and Y-score (partner→SCARA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	FoxM1 →	+0.298	+2.820	.047	.035	3	2
UCEC	eIF4E →	+0.242	+2.807	.008	.003	3	2
UCEC	JNK_pT183_Y185 →	-0.237	-2.794	.001	.003	3	2
UCEC	Chk2_pT68 →	-0.169	-3.312	.037	.010	2	3
UCEC	14-3-3_beta →	-0.144	-3.432	.001	.005	3	1
UCEC	A-Raf_pS299 →	-0.162	-3.321	.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

FoxM1 by SCARA5 expression — LUAD

Explore this box plot interactively →