SCAPER

Across TCGA pan-cancer cohorts, SCAPER mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SCAPER data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher SCAPER mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SCAPER expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

GBM, PDAC, and LUAD are the cancer types where SCAPER mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	DFS	Quartile	All	0.472	0.219	.001	20	view →
PDAC	DFS	Median	All	0.314	0.451	.015	9	view →
LUAD	DFS	Quartile	II,III,IV	0.612	0.972	.032	5	view →
LSCC	OS	Tertile	III,IV	0.521	0.918	.026	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SCAPER–GBM (DFS)

Open the GBM breakdown →