SCAPER

Across TCGA patient cohorts, SCAPER mutation is significantly associated with the RNA expression of many other genes, with 5,270 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCAPER-associated genes across cancer lineages are MIR302C, MIR623, and CCL5. Each is linked with SCAPER in more than 2 cancer types. Because this analysis shows association rather than direction, both SCAPER-to-partner and partner-to-SCAPER results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR302C grouped by SCAPER-low versus SCAPER-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCAPER→partner) and Y-score (partner→SCAPER) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	MIR302C →	+0.450	+4.771	<.001	.001	3	3
LIHC	MIR623 →	+0.413	+4.066	<.001	.004	3	3
UCEC	CCL5 →	+1.219	+2.423	<.001	<.001	3	3
UCEC	CCL4 →	+0.921	+2.191	<.001	<.001	3	3
READ	DSCR4-IT1 →	+0.301	+3.624	<.001	.004	3	3
UCEC	CXCL9 →	+2.430	+3.321	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,270 associations by consensus.

MIR302C by SCAPER expression — LIHC

Explore this box plot interactively →