SCAPER

Across TCGA cell cohorts, SCAPER mutation is significantly associated with the RNA expression of many other genes, with 49 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SCAPER-associated genes across cancer lineages are REG3G, IQCF6, and NOBOX. Each is linked with SCAPER in more than 1 cancer types. Because this analysis shows association rather than direction, both SCAPER-to-partner and partner-to-SCAPER results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, REG3G grouped by SCAPER-low versus SCAPER-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCAPER→partner) and Y-score (partner→SCAPER) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	REG3G →	+0.026	+4.867	.004	.009	3	2
LARGE_INTESTINE	IQCF6 →	+0.159	+2.560	.001	.008	3	2
URINARY_TRACT	NOBOX →	+0.016	+4.044	<.001	.001	3	1
URINARY_TRACT	LCE1B →	+0.048	+3.807	.002	.005	3	1
CNS	OR8B4 →	+0.036	+4.772	<.001	.002	3	1
LUNG_SCLC	OR2T6 →	+0.021	+3.614	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

REG3G by SCAPER expression — BLOOD_Lymphoma

Explore this box plot interactively →