SCAP

Across TCGA patient cohorts, SCAP RNA expression is significantly associated with the protein abundance of many other proteins, with 10,710 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SCAP-associated proteins across cancer lineages are SETD2, CCDC12, and GBF1. Each is linked with SCAP in more than 4 cancer types. Because this analysis shows association rather than direction, both SCAP-to-partner and partner-to-SCAP results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SCAP versus SETD2 in GBM, with a Pearson correlation of 0.48.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SCAP→partner) and Y-score (partner→SCAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SETD2 →	+0.352	+0.456	<.001	<.001	3	5
GBM	CCDC12 →	+0.568	+0.366	<.001	<.001	3	4
LSCC	GBF1 →	-0.231	-0.512	<.001	<.001	3	4
LSCC	HSPA14 →	+0.319	+0.439	.001	<.001	3	4
GBM	HSPA5 →	-0.331	-0.398	<.001	.001	3	4
GBM	CASP1 →	-0.473	-0.356	.002	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,710 associations by consensus.

SCAP vs SETD2 — GBM

Explore this scatter interactively →