SCAP

Across TCGA patient cohorts, SCAP mutation is significantly associated with the RNA expression of many other genes, with 4,138 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCAP-associated genes across cancer lineages are UBE2T, LETM1, and EXO1. Each is linked with SCAP in more than 4 cancer types. Because this analysis shows association rather than direction, both SCAP-to-partner and partner-to-SCAP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UBE2T grouped by SCAP-low versus SCAP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCAP→partner) and Y-score (partner→SCAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	UBE2T →	+0.498	+2.189	.002	<.001	3	5
UCEC	LETM1 →	+0.398	+2.457	<.001	<.001	3	4
UCEC	EXO1 →	+0.518	+2.179	.002	<.001	3	4
SKCM	GTSE1 →	+0.850	+3.597	<.001	.001	3	4
COAD	PSMD9 →	+0.339	+3.223	.002	.008	3	4
SKCM	MCM5 →	+0.610	+2.153	<.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,138 associations by consensus.

UBE2T by SCAP expression — UCEC

Explore this box plot interactively →