SCAP

Across TCGA patient cohorts, SCAP mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCAP-associated genes across cancer lineages are FOXO3a_pS318_S321, TFRC, and Caspase-7-cleavedD198. Each is linked with SCAP in more than 2 cancer types. Because this analysis shows association rather than direction, both SCAP-to-partner and partner-to-SCAP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by SCAP-low versus SCAP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCAP→partner) and Y-score (partner→SCAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.077	-1.916	.048	.004	3	3
UCEC	TFRC →	+0.416	+3.584	.012	.002	3	3
UCEC	Caspase-7-cleavedD198 →	+0.578	+1.785	.001	.007	3	3
COAD	FASN →	+0.489	+3.178	.010	.010	3	2
UCEC	14-3-3_beta →	-0.104	-2.060	.001	.004	3	2
UCEC	eIF4E →	+0.156	+2.920	.018	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

FOXO3a_pS318_S321 by SCAP expression — UCEC

Explore this box plot interactively →