SCAP

Across TCGA cell cohorts, SCAP RNA expression is significantly associated with the go_rna of many other GO terms, with 4,214 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SCAP-associated GO terms across cancer lineages are Epigenetic regulation of gene expression, Nucleosome disassembly, and Negative regulation of chromosome condensation. Each is linked with SCAP in more than 15 cancer types. Because this analysis shows association rather than direction, both SCAP-to-partner and partner-to-SCAP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Epigenetic regulation of gene expression grouped by SCAP-low versus SCAP-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SCAP→partner) and Y-score (partner→SCAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Epigenetic regulation of gene expression →	+0.087	+0.786	<.001	<.001	3	16
KIDNEY	Nucleosome disassembly →	+0.183	+1.081	<.001	<.001	3	15
SOFT_TISSUE	Negative regulation of chromosome condensation →	+0.175	+0.723	<.001	<.001	3	15
LIVER	Regulation of protein localization to chromatin →	+0.124	+0.674	<.001	.001	3	15
SOFT_TISSUE	Positive regulation of T-helper 17 cell lineage commitment →	+0.216	+0.684	<.001	<.001	3	15
STOMACH	Regulation of nucleotide-excision repair →	+0.163	+0.911	.002	.002	2	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,214 associations by consensus.

Epigenetic regulation of gene expression by SCAP expression — BONE

Explore this box plot interactively →