SCAP

Across TCGA cell cohorts, SCAP mutation is significantly associated with the RNA expression of many other genes, with 791 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SCAP-associated genes across cancer lineages are OXT, CENPL, and SMU1. Each is linked with SCAP in more than 1 cancer types. Because this analysis shows association rather than direction, both SCAP-to-partner and partner-to-SCAP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OXT grouped by SCAP-low versus SCAP-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCAP→partner) and Y-score (partner→SCAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	OXT →	+0.073	+4.807	<.001	.006	3	2
BLOOD_Leukemia	CENPL →	+0.635	+3.351	.002	.003	3	2
BLOOD_Leukemia	SMU1 →	+0.397	+3.351	.007	.003	3	2
LARGE_INTESTINE	GRSF1 →	+0.648	+3.364	<.001	.002	3	2
BLOOD_Leukemia	TSHB →	+0.116	+2.428	<.001	.005	3	2
BLOOD_Leukemia	USP37 →	+0.624	+3.351	.005	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 791 associations by consensus.

OXT by SCAP expression — BLOOD_Myeloma

Explore this box plot interactively →