Across TCGA pan-cancer cohorts, SCAMP4 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SCAMP4 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher SCAMP4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SCAMP4 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

PDAC, LUAD, and HNSC are the cancer types where SCAMP4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	All	0.545	0.902	.001	30	view →
LUAD	DFS	Median	III,IV	0.409	0.941	.010	14	view →
HNSC	OS	Median	II,III,IV	0.825	0.637	.012	9	view →
CCRCC	OS	Median	All	1.000	0.909	.019	5	view →
GBM	OS	Median	All	0.634	0.457	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: SCAMP4 tumor-vs-normal RNA expression · all SCAMP4 data types