SCAMP1

Across TCGA patient cohorts, SCAMP1 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCAMP1-associated genes across cancer lineages are p62 Lck ligand, eIF4E, and FOXO3a_pS318_S321. Each is linked with SCAMP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SCAMP1-to-partner and partner-to-SCAMP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by SCAMP1-low versus SCAMP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCAMP1→partner) and Y-score (partner→SCAMP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.519	+2.179	<.001	.034	3	2
UCEC	eIF4E →	+0.201	+2.820	.048	.035	3	1
UCEC	FOXO3a_pS318_S321 →	-0.147	-3.160	.014	.019	3	1
UCEC	IGFBP2 →	-0.951	-2.459	.002	.020	3	1
UCEC	Ku80 →	+0.287	+2.179	.011	.034	3	1
UCEC	MEK1 →	+0.412	+2.321	.019	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

p62 Lck ligand by SCAMP1 expression — UCEC

Explore this box plot interactively →