Across TCGA patient cohorts, SCAF8 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCAF8-associated genes across cancer lineages are eIF4E, Fibronectin, and Notch1. Each is linked with SCAF8 in more than 2 cancer types. Because this analysis shows association rather than direction, both SCAF8-to-partner and partner-to-SCAF8 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCAF8→partner) and Y-score (partner→SCAF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.211	+2.000	<.001	<.001	3	2
UCEC	Fibronectin →	-0.220	-1.382	.018	.017	3	2
UCEC	Notch1 →	+0.116	+1.293	.003	.031	3	2
UCEC	p21 →	+0.138	+1.925	.011	.004	3	2
UCEC	PCNA →	+0.258	+1.784	<.001	<.001	3	2
UCEC	ASNS →	+0.312	+1.523	.002	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

Exploration

SCAF8 survival (RNA) · tumor vs normal (RNA) · all SCAF8 data types