Across TCGA cell cohorts, SCAF8 mutation is significantly associated with the RNA expression of many other genes, with 106 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SCAF8-associated genes across cancer lineages are OTOP1, AVP, and KRTAP1-1. Each is linked with SCAF8 in more than 1 cancer types. Because this analysis shows association rather than direction, both SCAF8-to-partner and partner-to-SCAF8 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCAF8→partner) and Y-score (partner→SCAF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	OTOP1 →	+0.210	+5.087	<.001	.004	3	1
BLOOD_Lymphoma	AVP →	+0.031	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	KRTAP1-1 →	+0.068	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	KRTAP4-1 →	+0.151	+4.867	<.001	.009	3	1
BLOOD_Leukemia	HHLA1 →	+0.009	+3.551	<.001	.009	3	1
BLOOD_Leukemia	SLC6A17 →	+0.192	+4.037	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 106 associations by consensus.

Exploration

SCAF8 survival (RNA) · tumor vs normal (RNA) · all SCAF8 data types