SCAF4

Across TCGA pan-cancer cohorts, SCAF4 Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated SCAF4 data layer compared with 23 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher SCAF4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SCAF4 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

BRCA, SCLC, and UCEC are the cancer types where SCAF4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	All	0.668	0.964	<.001	28	view →
SCLC	OS	Median	II,III,IV	0.082	0.648	<.001	24	view →
UCEC	OS	Median	All	0.956	0.642	.006	20	view →
KIRC	DFS	Median	All	0.067	0.865	<.001	18	view →
ACC	DFS	Median	All	0.120	0.772	<.001	15	view →
LUAD	OS	Median	All	0.254	0.790	<.001	15	view →
ESCA	OS	Median	II,III,IV	0.345	0.686	.047	3	view →
SKCM	DFS	Median	II,III,IV	0.929	0.667	.031	3	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

SCAF4–BRCA (OS)

Open the BRCA breakdown →