SCAF4

Across TCGA pan-cancer cohorts, SCAF4 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SCAF4 data layer compared with 23 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SCAF4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SCAF4 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

HNSC, PDAC, and LUAD are the cancer types where SCAF4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.531	0.772	.003	11	view →
PDAC	DFS	Tertile	IV	0.752	0.199	.024	7	view →
LUAD	DFS	Median	II,III,IV	1.000	0.798	.015	6	view →
UCEC	DFS	Median	All	0.852	0.946	.036	2	view →
GBM	DFS	Median	All	0.447	0.303	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SCAF4–HNSC (DFS)

Open the HNSC breakdown →