SCAF4

Across TCGA cell cohorts, SCAF4 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,430 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SCAF4-associated GO terms across cancer lineages are mRNA alternative polyadenylation, Epigenetic regulation of gene expression, and Regulation of DNA repair. Each is linked with SCAF4 in more than 17 cancer types. Because this analysis shows association rather than direction, both SCAF4-to-partner and partner-to-SCAF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mRNA alternative polyadenylation grouped by SCAF4-low versus SCAF4-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SCAF4→partner) and Y-score (partner→SCAF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	mRNA alternative polyadenylation →	+0.082	+0.705	.001	<.001	3	18
OVARY	Epigenetic regulation of gene expression →	+0.069	+0.693	<.001	.001	3	18
LIVER	Regulation of DNA repair →	+0.077	+0.777	.001	.007	3	18
BONE	RNA export from nucleus →	+0.131	+0.746	<.001	<.001	3	18
BONE	Regulation of double-strand break repair via homologous recombination →	+0.107	+0.729	<.001	.001	3	17
OVARY	Regulation of termination of RNA polymerase II transcription →	+0.151	+0.824	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,430 associations by consensus.

mRNA alternative polyadenylation by SCAF4 expression — LARGE_INTESTINE

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