SCAF4

Across TCGA cell cohorts, SCAF4 mutation is significantly associated with the RNA expression of many other genes, with 1,100 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SCAF4-associated genes across cancer lineages are PADI6, IL1F10, and OPRK1. Each is linked with SCAF4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SCAF4-to-partner and partner-to-SCAF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PADI6 grouped by SCAF4-low versus SCAF4-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCAF4→partner) and Y-score (partner→SCAF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PADI6 →	+0.009	+4.169	<.001	.002	3	2
LUNG_NSCLC_LUAD	IL1F10 →	+0.185	+2.989	<.001	.007	3	2
LUNG_NSCLC_LUAD	OPRK1 →	+0.240	+3.263	.002	.009	3	2
BLOOD_Leukemia	CRKL →	+0.602	+3.351	.001	.003	3	2
LARGE_INTESTINE	HIRA →	+0.716	+3.459	<.001	<.001	3	2
LARGE_INTESTINE	CCDC134 →	+0.664	+1.628	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,100 associations by consensus.

PADI6 by SCAF4 expression — SOFT_TISSUE

Explore this box plot interactively →