SCAF11

Across TCGA pan-cancer cohorts, SCAF11 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SCAF11 data layer compared with 24 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher SCAF11 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SCAF11 expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

LSCC, CCRCC, and PDAC are the cancer types where SCAF11 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	II,III,IV	1.000	0.854	.002	18	view →
CCRCC	DFS	Tertile	III,IV	0.534	0.849	.005	13	view →
PDAC	DFS	Tertile	All	0.503	0.316	.013	11	view →
HNSC	DFS	Median	IV	0.692	0.920	.014	10	view →
LUAD	OS	Median	All	0.915	0.767	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SCAF11–LSCC (DFS)

Open the LSCC breakdown →