SCAF11

Across TCGA patient cohorts, SCAF11 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCAF11-associated genes across cancer lineages are PDCD4, Caspase-7-cleavedD198, and Notch1. Each is linked with SCAF11 in more than 3 cancer types. Because this analysis shows association rather than direction, both SCAF11-to-partner and partner-to-SCAF11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by SCAF11-low versus SCAF11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCAF11→partner) and Y-score (partner→SCAF11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.585	-1.999	<.001	<.001	3	4
UCEC	Caspase-7-cleavedD198 →	+0.604	+1.756	<.001	.003	3	4
UCEC	Notch1 →	+0.148	+1.754	<.001	.001	3	3
UCEC	4E-BP1_pT37_T46 →	-0.353	-2.234	.001	.001	3	3
UCEC	C-Raf →	+0.168	+1.754	<.001	.001	3	3
BLCA	EGFR_pY1068 →	+0.444	+2.820	.025	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

PDCD4 by SCAF11 expression — UCEC

Explore this box plot interactively →