SCAF1

Across TCGA pan-cancer cohorts, SCAF1 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SCAF1 data layer compared with 26 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SCAF1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SCAF1 expression acts as an unfavorable survival marker, although some lineages such as STAD and SCLC show a favorable association.

HNSC, LIHC, and LUAD are the cancer types where SCAF1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.189	0.752	<.001	54	view →
LIHC	DFS	Median	All	0.068	0.557	<.001	18	view →
LUAD	DFS	Median	IV	0.342	0.893	<.001	6	view →
STAD	DFS	Median	All	1.000	0.339	.042	4	view →
SCLC	OS	Median	IV	0.719	0.167	.035	3	view →
SKCM	DFS	Median	All	0.493	0.626	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SCAF1–HNSC (OS)

Open the HNSC breakdown →