SCAF1

Across TCGA pan-cancer cohorts, SCAF1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SCAF1 data layer compared with 26 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SCAF1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SCAF1 expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

HNSC, PDAC, and GBM are the cancer types where SCAF1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	IV	0.494	0.828	<.001	77	view →
PDAC	DFS	Median	IV	0.250	0.934	.024	6	view →
GBM	OS	Quartile	All	0.630	0.382	.044	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

SCAF1–HNSC (DFS)

Open the HNSC breakdown →