SCAF1

Across TCGA patient cohorts, SCAF1 mutation is significantly associated with the RNA expression of many other genes, with 3,789 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCAF1-associated genes across cancer lineages are EME1, CORO1C, and PSMC3IP. Each is linked with SCAF1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SCAF1-to-partner and partner-to-SCAF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EME1 grouped by SCAF1-low versus SCAF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCAF1→partner) and Y-score (partner→SCAF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EME1 →	+0.611	+2.126	<.001	<.001	3	3
UCEC	CORO1C →	+0.573	+1.840	<.001	.006	3	3
UCEC	PSMC3IP →	+0.628	+2.126	<.001	<.001	3	3
BLCA	MRPL50P4 →	+0.242	+4.618	<.001	.005	3	3
HNSC	MTCYBP34 →	+0.087	+5.241	<.001	.007	3	3
HNSC	LINC02297 →	+0.035	+6.468	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,789 associations by consensus.

EME1 by SCAF1 expression — UCEC

Explore this box plot interactively →