SC5D

Across TCGA pan-cancer cohorts, SC5D Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SC5D data layer compared with 25 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SC5D Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated SC5D expression acts as an unfavorable survival marker, although some lineages such as UCEC and STAD show a favorable association.

UCEC, LUSC, and SKCM are the cancer types where SC5D Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	1.000	0.620	.008	32	view →
LUSC	OS	Median	All	0.156	0.766	<.001	30	view →
SKCM	DFS	Median	II,III,IV	0.087	0.708	<.001	9	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
STAD	DFS	Median	II,III,IV	0.921	0.630	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SC5D–UCEC (DFS)

Open the UCEC breakdown →