SC5D

Across TCGA patient cohorts, SC5D mutation is significantly associated with the RNA expression of many other genes, with 2,590 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SC5D-associated genes across cancer lineages are PSAT1P4, OR5S1P, and MIR3661. Each is linked with SC5D in more than 1 cancer types. Because this analysis shows association rather than direction, both SC5D-to-partner and partner-to-SC5D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSAT1P4 grouped by SC5D-low versus SC5D-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SC5D→partner) and Y-score (partner→SC5D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PSAT1P4 →	+0.119	+1.701	.005	.007	3	2
LIHC	OR5S1P →	+0.042	+5.355	.001	.005	3	2
UCEC	MIR3661 →	+0.661	+1.768	<.001	.007	3	2
UCEC	PAMR1 →	-0.886	-3.568	.007	.002	3	1
UCEC	EIF3M →	+0.446	+3.648	.005	.001	3	1
UCEC	LAMTOR1 →	+0.341	+2.595	.005	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,590 associations by consensus.

PSAT1P4 by SC5D expression — UCEC

Explore this box plot interactively →